Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines

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Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines

Eriobotrya japonica leaf is a traditional herbal medicine that contains numerous triterpenes, which have various pharmacological properties. In this study, we investigated the anti-proliferative activity of four triterpenes derived from E. japonica, including corosolic acid (CA), ursolic acid (UA), maslinic acid (MA) and oleanolic acid (OA), in human leukemia cell lines. CA showed the strongest...

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Induction of Apoptosis in Human Leukemia Cell Line (HL60) by Animal’s Venom Derived Peptides (ICD-85)

Our previous studies revealed an inhibitory effect of ICD-85 (Venom derived peptides) on breast cancer cell line MDA-MB231. ICD-85 was also confirmed by in-vivo studies to suppress the breast tumor in mice. However, the exact mechanism of ICD-85 was unknown. Hence, the present study was undertaken to assess the mechanism of ICD-85 effect as an anti-proliferative agent of cancer cells. The effec...

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induction of apoptosis in human tumor cell lines by platelets

introduction: it has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. the effect of platelets on the induction of apoptosis in tumor cells is largely unknown. materials and methods: to investigate this effect, two human hematologic cell lines, k562 and daudi, were independently faced with unstimulated and thrombin-ac...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2013

ISSN: 1422-0067

DOI: 10.3390/ijms14024106